Since the beginning of 2018, articles on the dangerousness of flavoring for e liquid have been circulating in the media.

But are there more dangerous flavors than others when choosing a flavored e liquid or when making your own electronic cigarette e juice ?

We will try to see more clearly about the potential harmfulness of certain flavors and unravel some nodes of this vape question, by addressing these major points :

  1.     Studies on flavoring used in electronic cigarette products
  2.     The University of Rochester studies
  3.     The danger of flavors
  4.     Should we be afraid of flavors in e-liquids?
  5.     Study methodology
  6.     And what about cigarettes?
  7.     Eliminate the dangerous vape flavors



Studies on flavoring used in electronic cigarette products


Sure, you could not miss the catchy titles on many sites evoking a new study alerting on the possible harmfulness of the ecig flavors.

Since 2015, this subject is regularly relaunched in the media.

For example, Harvard University researchers tested 51 flavors for diacetyl, acetoin, and pentanedione.

As a result, they detected the presence of at least one of these substances in 47 of the 51 products.

The alert was thus given in 2015 regarding diacetyl and its potential involvement in triggering severe respiratory diseases ... far from proven as you can find in our article on diacetyl.

In the same year, a study from the University of Rochester concluded that certain flavors used in the ecigarette damage the mouse's epithelial cells, with special mention for cinnamon, fruity and sweet aromas.

The endless alert relayed in the media is thus launched: the electronic cigarette damages the lungs.

In 2017, the University of Kentucky tests 55 flavor components on cardiomyocites, cardiac muscle cells, and this time points to citrus, cinnamon and clove flavors to conclude that they are potentially harmful to the heart, posing a serious question on methodology.

Then the University of Virginia publishes a new study on the effects of six electronic cigarette scents on tadpoles, concluding that some had developed a cleft lip and palate, also known as a hare's beak.
We then learned that 20% of tadpoles exposed to raspberry, almond, caramel, vanilla, biscuit and Viennese cream flavors had a hare beak, and up to 70% for those having been subjected to cereals, berries, cream and lemon flavors.

I leave you free appreciation on this study very useful for the tadpoles!

In 2018, the University of Rochester publishes a new study in which researchers note a significant inflammatory reaction on monocytes (white blood cells), specific cells of the immune system, in contact with vanilla, cinnamon and butter flavors as well as certain mixtures.



The University of Rochester studies



We don't want to underestimate the conclusions of the studies mentioned above, but we can only be surprised when we make the list of studies carried out by the University of Rochester on the electronic cigarette.

A simple research tells us that this university has a pretty amazing record in the field.

To date, and as each of the studies has been conducted, researchers at this university have come to the conclusion that:


     - the electronic cigarette and its flavors damage the gums and teeth

     - the electronic cigarette and its flavors damage the lungs

     - the electronic cigarette and its flavors have an impact on the immune system

     - the electronic cigarette and its flavors have an impact on wound healing


One may legitimately be surprised by so much interest in research on this electronic device.
But not that much ...

Looking deeper, we learn that in 2014, the University of Rochester received a budget of more than $ 2 million to conduct a series of studies on the e-cigarette and its products.

Such an investment could be welcomed to ensure the safety of this alternative to tobacco if this budget had not been allocated by the US Food and Drug Administration (FDA) for the purpose of place a regulation based on scientific research.

From there, to understand that Dr. Irfan Rahman, who has been doing most of these studies for the last 4 years through his Rahman Lab, is somewhat biased when he concludes:


          " Currently, these are not regulated and alluring flavour names, such as candy, cake, cinnamon roll and mystery mix, attract young vapers.

Researchers said tighter regulations are necessary to reduce the risk of 'inhalation toxicity' due to exposure to vaping flavouring chemicals.

E-juice bottles must have a descriptive listing of all ingredients. We urge regulatory agencies to act to protect public health."


To superimpose Dr. Irfan Rahman's statements and the strict regulation that the FDA wants to impose on eliquids by banning sweet, candy, cinnamon and coffee flavors, which are considered too attractive for the youth, would certainly be somewhat insolent!

We will not allow it, but we can only emphasize the fact that the two major studies on flavorings published in one year come from an FDA-funded university that continues its program of regulation of the electronic cigarette in the United States and seems to find the support of the mandated scientists.

On the University of Rochester website, Dr. Irfan Rahman's team is delighted with the impressive sharing of their latest study in the media around the world, even publishing statistics:


          "Currently, the article has been viewed more than 16,500 times (in one day) and several news sources have written articles and reported around the world.", we read.

Mission accomplished.

junk science

The danger of flavors


If we have the right to do some "slips" on the studies emanating from the University of Rochester, it remains that the alerts on certain flavors really existed.

In 2013, the Clearstream Life study conducted by Dr Romano and Farsalinos for Flavour Art revealed a mild cytotoxicity of maximum concentration coffee flavor.

Today, Dr. Farsalinos, cardiologist invested in research on the electronic cigarette, although fervent defender of the diversity of the flavors available to allow the majority to switch to vape, puts all the same cautions and invites the vapers to measure their ejuice in moderation when they do it themselves and do not overuse the power of their electronic mod until the flavor data is supported.

Should we be afraid of flavors in eliquids?


To tell the truth, at the moment scientific studies are not sufficiently documented to be formal and allow to exclude this or that flavor.

But the little we already know sheds light on how to handle apprehensions.

What these studies highlight about flavors are not the tastes themselves.

It does not make sense to say that vanilla, cinnamon or coffee aroma is potentially harmful to the vaper.
In fact, it would be more accurate to determine which component constituting a vanilla, cinnamon or coffee flavor can be potentially harmful.

Take, for example, the first The Flavor Apprentice vanilla custard flavor.
Its exact composition revealed by the manufacturer is:


      •     propylene glycol
      •     vanillin
      •     benzyl alcohol
      •     ethyl vanillin
      •     piperonal
      •     benzyl benzoate
      •     maltol
      •     acetoin
      •     acetyl propionyl
      •     butyrin



Today, we know that in this composition, acetyl propionyl and acetoin will be eliminated as a precaution, part of the diketones family, just like diacetyl previously removed from our liquids and flavors.

This is what Perfumer's Apprentice (and most manufacturers, see the Vanilla Custard v2 Capella flavor) has done by proposing a second version without these two components.

Now, if scientists need to warn about the potential danger of a vanilla flavor, should vanillin, ethyl vanillin and piperonal be mentioned here as they give this aroma its vanilla taste ?


In the same way, if scientists should warn about the cinnamon flavor in eliquids, should not they rather evoke cinnamaldehyde?

The possible concern of the flavors is in the aldehydes which compose them.
And the results of studies submitted to date can not be limited to stipulating that fruity or creamy flavors must be eliminated, but which specific aldehydes contained in a flavor display a real toxicity, at what dose and according to which use.

With the exception of Dr. Farsalinos and Flavour Art, no study has come to specify what are the undesirable aldehydes in the vape flavors

aldehyde in flavors



Study methodology


In addition, most of these studies show a questionable methodology.

Most are conducted on mice, sometimes even tadpoles (!), exposing them to steam produced by smoking machines.

They want to be alarmist while not reproducing the real conditions of the use of the electronic cigarette.
And when we know that overheat resistance or wick improperly wetted  denature an e liquid and produce toxic substances, we can question the scientists on the veracity of their claims.

As for the latest study from the University of Rochester, cells are exposed to diacetyl, cinnamaldehyde, acetoine, pentanedione, o-vanillin, maltol and coumarin at different doses.

We are not even in an e-cigarette environment until unidentified flavored and nicotine-free juices are tested in the process.

This simple test allows the authors to conclude that some flavored eliquids have a potential harmful effect.

Does this mean that the food flavors we regularly face without even being vaping are dangerous for health at high concentration?...


food flavors



And at the same time, in March 2018, Dr. Farsalinos published the results of his latest study on the presence of aldehydes in ecigarette vapor in real test with flavored and non-flavored e liquids and concluded:



          " The e-cigarettes tested here emit very low levels of aldehydes. Some flavors may contribute to aldehyde emissions, but the rates are minimal.
Validated methods should be used when analyzing e-cigarette emissions."


His study has shown that flavored eliquids produce an emission of formaldehyde, acetaldehyde and acrolein 79 to 99.8% lower than cigarette smoke and also lower than the rate of aldehydes in the air we breathe when previous alerts denounced the presence of these potentially carcinogenic toxic substances.

No media has echoed this study to date, not even those who have claimed worldwide "the electronic cigarette is carcinogenic".


What about cigarettes ?



The flavors of the electronic cigarette are pointed out. They are dangerous. They are toxic. They risk triggering irreversible diseases. The electronic cigarette is dangerous!

Well but, are there such alarms when we know that the cigarette so generously made available to all to the delight of the tax administration contains:

           - fruit, rum, licorice, menthol, vanillin, caramel, ethyl maltol, ethyl vanillin, vanilla, coffee, lemon, coriander, nail cloves, orange, cinnamon, cumin, ginger, nutmeg, lemon...

297 flavors identified in tobacco. No alerts in sight ...


Eliminate the dangerous vape flavors


Once again the alerts are not a definitive argument.
In the absence of in-depth studies on the impact of certain aldehydes on health, we can not eliminate this or that taste.

And even if we know which aldehyde is problematic, other elements such as its dosage in the flavor, its dilution in the e liquid, temperature threshold not to cross ... should also be specified to obtain an assessment of its actual toxicity threshold.

Of course, we strongly advise moderation.
Do not make a liquid by adding 40 or 50% flavor! Have a light hand, avoid overheating, in short, caution.


Conclusion


The ongoing studies of flavors today are not viable at the time the FDA is trying to remove them from the US market, claiming they are attractive to youth.

Of course, it is best to let a young person smoke rather than tempt him with a taste of strawberry candy in an electronic cigarette eliquid!

Unless it is even smarter to remove the flavored e-liquids so that smokers never hear again about this mysterious electronic device that can possibly replace the cigarette...



Resources:

Rochester University 2015 https://www.urmc.rochester.edu/news/story/4253/e-cigarette-vapors-flavorings-trigger-lung-cell-stress.aspx

Rochester University 2016 https://www.urmc.rochester.edu/news/story/4667/first-ever-study-shows-e-cigarettes-cause-damage-to-gum-tissue.aspx

Rochester University 2018 https://www.frontiersin.org/articles/10.3389/fphys.2017.01130/full

Kentucky University 2017 http://circ.ahajournals.org/content/136/Suppl_1/A20782

Harvard University 2015 https://ehp.niehs.nih.gov/15-10185/